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Before taking amantadine

This may help prevent diarrhea. SYMMETREL Amantadine Hydrochloride, USP 100 mg TID for Parkinson's disease. Sphincter cuff device. A surgeon can implant an inflatable cuff that surrounds the anal sphincter. A person deflates the cuff during bowel movements and reinflates it to prevent bowel incontinence. price for cardura at walmart

What are the possible side effects of amantadine

Keratitis and mydriasis have been reported during postmarketing experience. The total daily dose is 200 mg given as one tablet of 100 mg twice a day. The 100 mg daily dose has not been studied in this pediatric population. Therefore, there are no data which demonstrate that this dose is as effective as or is safer than the 200 mg daily dose in this patient population. Although some strains of avian influenza A H5N1 have been susceptible to amantadine, 38 42 126 avian influenza A virus strains tested including H5N1 and H7N9 generally are resistant to adamantanes. Recommended composition of influenza virus vaccines for use in the 2007-2008 influenza season. Wkly Epidemiol Rec.

What is flu influenza?

Amantadine is used to treat and prevent influenza A a viral infection. Amantadine may not be effective during every flu season because certain strains of influenza virus may be resistant to this medicine. Amantadine-resistant influenza A viruses also are resistant to rimantadine and vice versa. The adverse effects of amantadine are generally mild and, when they occur, may diminish or cease after a week or more on the medication.

List of amantadine side effects

Adamantane-derivative a symmetric tricyclic amine; 1 2 6 26 27 44 45 structurally related to rimantadine. Clover RD, Crawford SA, Abell TD et al. Effectiveness of rimantadine prophylaxis of children within families. Am J Dis Child. Hayden FG. Antiviral agents: other antiviral agents. In: Hardman JG, Goodman LS, Gillman A et al, eds. Goodman and Gilman's the pharmacological basis of therapeutics.



About amantadine

Dolin R, Reichman RC, Madore HP, et al "A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. Use with caution in patients with recurrent eczematoid dermatitis. Parkinson disease: Treatment of idiopathic Parkinson disease paralysis agitans postencephalitic parkinsonism, parkinsonism in association with cerebral arteriosclerosis, and symptomatic parkinsonism, which may follow injury to the nervous system by carbon monoxide intoxication. Untreated influenza infection is associated with an increased risk of adverse events to the fetus and an increased risk of complications or death to the mother. Other agents are currently recommended for the treatment or prophylaxis influenza in pregnant women and women up to 2 weeks postpartum. Appropriate antiviral agents are currently recommended as an adjunct to vaccination and should not be used as a substitute for vaccination in pregnant women CDC 2011; CDC 2014. Borison RL "Amantadine-induced psychosis in a geriatric patient with renal disease. Sporadic cases of possible Neuroleptic Malignant Syndrome NMS have been reported in association with dose reduction or withdrawal of Symmetrel therapy. Therefore, patients should be observed carefully when the dosage of Symmetrel is reduced abruptly or discontinued, especially if the patient is receiving neuroleptics. For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using amantadine hydrochloride tablets for any indication. If you miss a dose, use it as soon as you remember. not use this 2 days in a row. Do not double the dose to catch up. Follow your usual schedule the next week.



Reviews for amantadine

Amantadine should be continued for at least 10 days after known exposure. The management of NMS should include: 1 intense symptomatic treatment and medical monitoring, and 2 treatment of any concomitant serious medical problems for which specific treatments are available. Dopamine agonists, such as bromocriptine, and muscle relaxants, such as dantrolene are often used in the treatment of NMS, however, their effectiveness has not been demonstrated in controlled studies. Aoki FY, Stiver HG, Sitar DS et al. Prophylactic amantadine dose and plasma concentration-effect relationships in healthy adults. Clin Pharmacol Ther. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Use with caution in patients with liver disease. 1 2 6 Increased concentrations of liver enzymes reported. Across studies, the time to C max T max averaged about 2 to 4 hours. Shealy CN et al. Livedo reticularis in patients with parkinsonism receiving amantadine. JAMA. The initial dose of amantadine hydrochloride tablets is 100 mg daily for patients with serious associated medical illnesses or who are receiving high doses of other antiparkinson drugs. After one to several weeks at 100 mg once daily, the dose may be increased to 100 mg twice daily, if necessary. Occasionally, patients whose responses are not optimal with amantadine hydrochloride tablets at 200 mg daily may benefit from an increase up to 400 mg daily in divided doses. However, such patients should be supervised closely by their physicians. The total daily dose is 200 mg given as two teaspoonfuls of oral solution twice a day. The 100 mg daily dose has not been studied in this pediatric population. Therefore, there are no data which demonstrate that this dose is as effective as or is safer than the 200 mg daily dose in this patient population. The dose of anticholinergic drugs or of SYMMETREL amantadine hydrochloride should be reduced if atropine-like effects appear when these drugs are used concurrently. Kimberlin DW, Whitley RJ. Antiviral resistance: mechanisms, clinical significance, and future implications. J Antimicrob Chemother. Take this medication at least 1 hour before antacids containing magnesium, aluminum, or calcium. Allow at least 1-2 hours between doses of trihexyphenidyl and certain drugs for diarrhea adsorbent antidiarrheals such as kaolin, pectin, attapulgite. Take this medication at least 2 hours after ketoconazole. Antacids and some drugs for diarrhea may prevent the full absorption of trihexyphenidyl, and this product may prevent the complete absorption of ketoconazole when these products are taken together. desloratadine



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The usual dose of amantadine hydrochloride is 100 mg twice a day. Occasionally, patients whose responses are not optimal with amantadine hydrochloride at 200 mg daily may benefit from an increase up to 300 mg daily in divided doses. Inject this medication into a muscle as directed by your doctor, usually once a week. It is best to use this medication near to reduce side effects. Postmarketing reports suggest that patients treated with anti-Parkinson medications can experience intense urges to gamble, increased sexual urges, intense urges to spend money uncontrollably, and other intense urges. Patients may be unable to control these urges while taking one or more of the medications that are generally used for the treatment of Parkinson's disease and that increase central dopaminergic tone, including amantadine hydrochloride. In some cases, although not all, these urges were reported to have stopped when the dose was reduced or the medication was discontinued. Because patients may not recognize these behaviors as abnormal it is important for prescribers to specifically ask patients or their caregivers about the development of new or increased gambling urges, sexual urges, uncontrolled spending or other urges while being treated with amantadine hydrochloride. Physicians should consider dose reduction or stopping the medication if a patient develops such urges while taking amantadine hydrochloride. What are the possible side effects of amantadine Symmetrel? Substantially eliminated by the kidneys. 1 2 6 Consider age-related decreases in renal function and the potential for concomitant disease when selecting dosage. 1 2 6 See Geriatric Patients under Dosage and Administration. Smith EJ "Amantadine-induced psychosis in a young healthy patient. Less frequently 1-5% reported adverse reactions are: depression, anxiety and irritability, hallucinations, confusion, anorexia, dry mouth, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, nervousness, dream abnormality, agitation, dry nose, diarrhea and fatigue. Close monitoring for undue adverse effects is highly recommended. For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using amantadine hydrochloride for any indication. When SYMMETREL amantadine hydrochloride or anticholinergic antiparkinson drugs are each used with marginal benefit, concomitant use may produce additional benefit. Registered Trademark of Endo Pharmaceuticals Inc. Care should be exercised when administering Symmetrel to patients with liver disease. Rare instances of reversible elevation of liver enzymes have been reported in patients receiving Symmetrel, though a specific relationship between the drug and such changes has not been established. Amantadine hydrochloride oral solution USP is indicated in the treatment of drug-induced extrapyramidal reactions. Although anticholinergic-type side effects have been noted with Amantadine Hydrochloride when used in patients with drug-induced extrapyramidal reactions, there is a lower incidence of these side effects than that observed with the anticholinergic antiparkinson drugs. Cardiovascular disease: Use with caution in patients with heart failure, peripheral edema, or orthostatic hypotension; dosage reduction may be required. When amantadine hydrochloride is added to optimal well-tolerated doses of levodopa, additional benefit may result, including smoothing out the fluctuations in improvement which sometimes occur in patients on levodopa alone. Patients who require a reduction in their usual dose of levodopa because of development of side effects may possibly regain lost benefit with the addition of amantadine hydrochloride. pharmacy coupons for ranexa ranexa



Amantadine brand names

Care should be exercised when administering adrenergic agents, such as isoproterenol, to patients with a Symmetrel overdose, since the dopaminergic activity of Symmetrel has been reported to induce malignant arrhythmias. The usual dose of amantadine hydrochloride is 100 mg twice a day when used alone. Amantadine hydrochloride has an onset of action usually within 48 hours. Aoki FY, Sitar DS. Amantadine kinetics in healthy elderly men: implications for influenza prevention. Clin Pharmacol Ther. SYMMETREL amantadine hydrochloride is indicated for against signs and symptoms of influenza A virus infection. Store in the refrigerator away from light. not freeze. This may also be stored at room temperature for up to 7 days. Keep all away from children and pets. Avoid excessive alcohol usage, since it may increase the potential for CNS effects such as dizziness, confusion, lightheadedness and orthostatic hypotension. Alcohol Ethyl: May enhance the CNS depressant effect of Amantadine. Gaudry SE, Sitar DS, Smyth DD et al. Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine. Clin Pharmacol Ther. When Amantadine Hydrochloride Capsules, USP is added to optimal well-tolerated doses of levodopa, additional benefit may result, including smoothing out the fluctuations in improvement which sometimes occur in patients on levodopa alone. Patients who require a reduction in their usual dose of levodopa because of development of side effects may possibly regain lost benefit with the addition of Amantadine Hydrochloride Capsules, USP. Centers for Disease Control and Prevention CDC. Update: influenza activity - United States, August 30, 2009-March 27, 2010, and composition of the 2010-11 influenza vaccine. MMWR Morb Mortal Wkly Rep. There is no specific antidote for an overdose of Symmetrel. Eat 20 to 30 grams of fiber per day. This can make stool more bulky and easier to control. Large doses of and minerals, such as or zinc. cheap pyridium vancouver



Important information

Product Information. Symmetrel amantadine. Miscellaneous - neuroleptic malignant syndrome see allergic reactions including anaphylactic reactions, edema and and fever. For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using Symmetrel for any indication. Patients with Parkinson's disease improving on SYMMETREL amantadine hydrochloride should resume normal activities gradually and cautiously, consistent with other medical considerations, such as the presence of or phlebothrombosis. Sometimes, the first symptoms are in your eyes and include double vision. Centers for Disease Control and Prevention. The dose of amantadine hydrochloride may need careful adjustment in patients with congestive heart failure, peripheral edema, or orthostatic hypotension. Care should be exercised when administering amantadine hydrochloride to patients with a history of recurrent eczematoid rash, or to patients with psychosis or severe psychoneurosis not controlled by chemotherapeutic agents. Exercises. Begin a program of regularly contracting the muscles used to control urinary flow . This builds strength in the pelvic muscles and may help reduce bowel incontinence. Nonsurgical treatments are often recommended as initial treatment for bowel incontinence. If you are using the liquid form of this medication, measure your dose with a special measuring spoon or device. Do not use a household spoon because it may not provide the correct dose. Because amantadine hydrochloride has anticholinergic effects and may cause mydriasis, it should not be given to patients with untreated angle closure glaucoma. Possible neuroleptic malignant syndrome NMS reported; associated with dosage reduction or withdrawal of amantadine. 1 2 6 Observe patients closely when dosage is reduced or the drug discontinued; this precaution is especially important in patients receiving concomitant therapy with an antipsychotic agent.



Where can I get more information?

Because Symmetrel is mainly excreted in the urine, it accumulates in the plasma and in the body when renal function declines. TID for Parkinson's disease. Patient may experience nausea or insomnia. Have patient report immediately to prescriber behavioral changes, confusion, severe dizziness, passing out, hallucinations, seizures, shortness of breath, excessive weight gain, swelling of arms or legs, difficult urination, blurred vision, uncontrollable urges, change in balance, signs of depression suicidal ideation, anxiety, emotional instability, or confusion agitation, irritability, panic attacks, mood changes, skin growths, mole changes, or signs of neuroleptic malignant syndrome fever, muscle cramps or stiffness, dizziness, severe headache, confusion, change in thinking, tachycardia, abnormal heartbeat, or sweating a lot HCAHPS. Patients with a history of epilepsy or other “seizures” should be observed closely for possible increased seizure activity. The most common cause of bowel is damage to the muscles around the anal sphincters. Vaginal can damage the anal sphincters or their nerves. That's why women are affected by accidental bowel leakage about twice as often as men. These minimally invasive procedures can reduce bowel incontinence in some people, without the risks of surgery. Because they are relatively new, their long-term effectiveness and safety aren't as well known as other treatments. Braley, TJ; Chervin, RD Aug 2010. Smordintsev AA et al. Evaluation of amantadine in artificially induced A 2 and B influenza. JAMA. The total daily dose is 200 mg given as one capsule of 100 mg twice a day. The 100 mg daily dose has not been studied in this pediatric population. Therefore, there are no data which demonstrate that this dose is as effective as or is safer than the 200 mg daily dose in this patient population. Nestelbaum Z, Siris SG, Rifkin A, Klar H, Reardon GT "Exacerbation of schizophrenia associated with amantadine. cvs brand of maxalt



TID for Parkinson's disease

What is the prognosis for patients who get the flu? Consult your doctor before -feeding. Do not share this medication with others. Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same times each day. What other drugs will affect amantadine? Some patients who do not respond to anticholinergic antiparkinson drugs may respond to Amantadine Hydrochloride Capsules, USP. When Amantadine Hydrochloride Capsules, USP or anticholinergic antiparkinson drugs are each used with marginal benefit, concomitant use may produce additional benefit. Anti-Parkinson Agents Dopamine Agonist. Management: Avoid concomitant therapy if possible and monitor for decreased effects of both agents when these combinations cannot be avoided. Atypical antipsychotics such as clozapine and quetiapine may be less likely to reduce the effects of anti-Parkinson agents. This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages. The pH of the urine has been reported to influence the excretion rate of amantadine hydrochloride. Since the excretion rate of amantadine hydrochloride increases rapidly when the urine is acidic, the administration of urine acidifying drugs may increase the elimination of the drug from the body. If you take amantadine for Parkinson symptoms: You should not stop using amantadine suddenly or your condition may become worse. When SYMMETREL amantadine hydrochloride is added to optimal well-tolerated doses of levodopa, additional benefit may result, including smoothing out the fluctuations in improvement which sometimes occur in patients on levodopa alone. Vollum DI. Livedo reticularis during amantadine treatment. Across studies, the time to Cmax Tmax averaged about 2 to 4 hours. Patients receiving Symmetrel who note central nervous system effects or blurring of vision should be cautioned against driving or working in situations where alertness and adequate motor coordination are important. Are the two objects side by side, or is one on top of the other? price of epivir at cvs epivir



How to use amantadine

Treatment of influenza A virus illness should be started as soon as possible, preferably within 24 to 48 hours after onset of signs and symptoms, and should be continued for 24 to 48 hours after the disappearance of signs and symptoms. Musculoskeletal side effects have included elevated creatine kinase during postmarketing experience. Acta Pharmacologica et Toxicologica, Nordic Pharmacological Society. Take this medicine with a full glass of water. If you take this medicine for Parkinson symptoms, your doctor may occasionally change your dose to make sure you get the best results. Whether these changes are due to decline in renal function or other age related factors is not known. Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose. Care should be exercised when administering adrenergic agents, such as isoproterenol, to patients with a amantadine hydrochloride overdose, since the dopaminergic activity of amantadine hydrochloride has been reported to induce malignant arrhythmias. Influenza Division, National Center for Immunization and Respiratory Diseases, CDC. Prevention and control of seasonal influenza with vaccines. MMWR Recomm Rep. Importance of consulting clinician before discontinuing amantadine. Hayden FG, Minocha A, Spyker DA et al. Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults. Antimicrob Agents Chemother. When Amantadine Hydrochloride Tablets and levodopa are initiated concurrently, the patient can exhibit rapid therapeutic benefits. Amantadine Hydrochloride Tablets should be held constant at 100 mg daily or twice daily while the daily dose of levodopa is gradually increased to optimal benefit. When does flu season begin and end? What are the causes of the flu influenza? Has been recommended as alternative for treatment or prophylaxis of avian influenza A virus infections in certain situations. Inhibits viral replication by interfering with the influenza A virus M2 protein, an integral membrane protein. flonase



What are the causes of the flu influenza?

Hayden FG, Sperber SJ, Belshe RB et al. Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine. Antimicrob Agents Chemother. The initial dose of Amantadine Hydrochloride Capsules, USP is 100 mg daily for patients with serious associated medical illnesses or who are receiving high doses of other antiparkinson drugs. After one to several weeks at 100 mg once daily, the dose may be increased to 100 mg twice daily, if necessary. Importance of seeking immediate medical attention for suspected overdose. Little JW et al. Amantadine effect on peripheral airway abnormalities in influenza. Ann Intern Med. Do not abruptly discontinue amantadine in patients with parkinsonian syndrome; some patients have developed parkinsonian crises after abrupt discontinuance of the drug. 1 2 6 Abrupt discontinuance also may precipitate delirium, agitation, delusions, hallucinations, paranoid reaction, stupor, anxiety, depression, and slurred speech. Neumayer EM et al. Antiviral activity of amantadine in tissue culture and in ovo. Proc Soc Exp Biol Med. Some antiviral medicines reduce the severity and shorten the duration of symptoms by 1 to 1½ days if given within 48 hours of the first symptoms. These medicines are not intended to substitute for getting a each year. Rather, antiviral medicines may help control outbreaks and prevent the spread of infection, especially in people at for complications. The adverse reactions reported most frequently at the recommended dose of amantadine 5-10% are: nausea, dizziness lightheadedness and insomnia. Amantadine is an antiviral medicine that blocks the actions of viruses in your body. That can lead to double vision. Hay AJ. The action of adamantanamines against influenza A viruses: inhibition of the M2 ion channel protein. Semin Virol. Nora JJ et al. Cardiovascular maldevelopment associated with maternal exposure to amantadine. Lancet. Cover one eye, then switch. Does the problem go away when either eye is covered?



Svensson, T H November 1971

Care should be exercised when administering adrenergic agents, such as isoproterenol, to patients with an amantadine hydrochloride overdose, since the dopaminergic activity of amantadine hydrochloride has been reported to induce malignant arrhythmias. Recommended treatments vary according to the cause of bowel incontinence. Often, more than one treatment method may be required to control symptoms. Anti-Parkinson Agents Dopamine Agonist. Aoki FY, Sitar DS. Clinical pharmacokinetics of amantadine hydrochloride. Clin Pharmacokinet. Adjust dose based on renal function; some patients tolerate the drug better when it is given in 2 divided daily doses to avoid adverse neurologic reactions. Symmetrel is excreted in human milk. Use is not recommended in nursing mothers. Pearce LA et al. Amantadine hydrochloride: alteration in peripheral circulation. Neurology. Seasonal influenza A H3N2 and influenza A H1N1pdm09 viruses circulating during recent influenza seasons have been resistant to adamantanes amantadine, rimantadine. Patients with a history of epilepsy or other "seizures" should be observed closely for possible increased seizure activity. The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Use this medication regularly to get the most benefit from it. To help you remember, use it on the same day each week. Propylene glycol: Some dosage forms may contain propylene glycol; large amounts are potentially toxic and have been associated hyperosmolality, lactic acidosis, seizures and respiratory depression; use caution AAP 1997; Zar 2007. Bowel training. Schedule bowel movements at the same times each day. This can help prevent accidents in between. Practice GLP and according to current recommended methodology. Amantadine hydrochloride oral solution USP is indicated for chemoprophylaxis against signs and symptoms of influenza A virus infection. Because amantadine hydrochloride does not completely prevent the host immune response to influenza A infection, individuals who take this drug may still develop immune responses to natural disease or vaccination and may be protected when later exposed to antigenically related viruses. Following vaccination during an influenza A outbreak, amantadine hydrochloride prophylaxis should be considered for the 2- to 4-week time period required to develop an antibody response. order dapoxetine us canada uk



Highlights for amantadine

Dysphasia has been reported during postmarketing experience. What should I avoid while taking amantadine Symmetrel? What is the incubation period for the flu? NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermia; neurologic findings including muscle rigidity, involuntary movements, altered consciousness; mental status changes; other disturbances such as autonomic dysfunction, tachycardia, tachypnea, hyper- or hypotension; laboratory findings such as creatine phosphokinase elevation, leukocytosis, myoglobinuria, and increased serum myoglobin. Drinking alcohol with this medicine can cause side effects. The management of NMS should include: 1 intensive symptomatic treatment and medical monitoring, and 2 treatment of any concomitant serious medical problems for which specific treatments are available. Dopamine agonists, such as bromocriptine, and muscle relaxants, such as dantrolene are often used in the treatment of NMS, however, their effectiveness has not been demonstrated in controlled studies. urza.info terbinafine



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Indications and usage of amantadine


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Amantadine and rimantadine have little or no activity against influenza B; not used for treatment of influenza B infection. Amantadine hydrochloride is not a substitute for early vaccination on an annual basis as recommended by the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices. Sears SD, Clements ML. Protective efficacy of low-dose amantadine in adults challenged with wild-type influenza A virus. Antimicrob Agents Chemother. Paralysis Agitans postencephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication. It is indicated in those elderly patients believed to develop parkinsonism in association with cerebral arteriosclerosis. oxybutynin in store coupons

What should i avoid while taking amantadine

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. If you are currently using the medication listed above, tell your doctor or pharmacist before starting amantadine. Centers for Disease Control and Prevention CDC. Influenza activity--United States, 2012-13 season and composition of the 2013-14 influenza vaccine. MMWR Morb Mortal Wkly Rep. MiFEPRIStone: May enhance the QTc-prolonging effect of QTc-Prolonging Agents Indeterminate Risk and Risk Modifying. Management: Though the drugs listed here have uncertain QT-prolonging effects, they all have some possible association with QT prolongation and should generally be avoided when possible. hydrea

How should i store amantadine

H1N1pdm09 virus circulating during recent influenza seasons is resistant to amantadine and rimantadine. Two antiviral medicines, oseltamivir and zanamivir, can treat and prevent influenza A and B infections. NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermia; neurologic findings including muscle rigidity, involuntary movements, altered consciousness; mental status changes; other disturbances such as autonomic dysfunction, tachycardia, tachypnea, hyper - or hypotension; laboratory findings such as creatine phosphokinase elevation, leukocytosis, myoglobinuria, and increased serum myoglobin.

Amantadine dosage

Symmetrel is available in tablets and syrup. Suicide attempts, some of which have been fatal, have been reported in patients treated with amantadine hydrochloride, many of whom received short courses for influenza treatment or prophylaxis. The incidence of suicide attempts is not known and the pathophysiologic mechanism is not understood. Suicide attempts and suicidal ideation have been reported in patients with and without prior history of psychiatric illness. Amantadine hydrochloride can exacerbate mental problems in patients with a history of psychiatric disorders or substance abuse. Patients who attempt suicide may exhibit abnormal mental states which include disorientation, confusion, depression, personality changes, agitation, aggressive behavior, hallucinations, paranoia, other psychotic reactions, and somnolence or insomnia. Because of the possibility of serious adverse effects, caution should be observed when prescribing amantadine hydrochloride tablets to patients being treated with drugs having CNS effects, or for whom the potential risks outweigh the benefit of treatment.

Arden NH, Patriarca PA, Pasano MD et al. The roles of vaccination and amantadine prophylaxis in controlling an outbreak of influenza A H3N2 in a nursing home. Arch Intern Med. Additional benefit may result from adding amantadine to optimal well-tolerated doses of levodopa; such benefit includes smoothing out improvement fluctuations that can occur with levodopa alone. Patients who reduce levodopa dose due to side effects may regain lost benefit with the addition of amantadine. SYMMETREL amantadine hydrochloride is indicated in the treatment of drug-induced extrapyramidal reactions. Although anticholinergic-type side effects have been noted with SYMMETREL amantadine hydrochloride when used in patients with drug-induced extrapyramidal reactions, there is a lower of these side effects than that observed with the anticholinergic antiparkinson drugs.

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